In the Pipeline
As of June 30, 2010

Bristol-Myers Squibb’s pipeline is one of the most innovative in the industry. Learn more about the medicines we are developing.

Exploratory Development
(Post discovery through Phase II)
Full Development (Registrational, Filed) Marketed Product Development (Approved in at least one major market)
Adnectin Bispecific (oncology) Ipilimumab (oncology) SPRYCEL® (dasatinib)
(oncology)
VEGF R-2 Adnectin (oncology) Brivanib (oncology) ERBITUX® (cetuximab)
(oncology)
ErbB/VEGF inhibitor (oncology) Necitumumab (oncology) IXEMPRA® (ixabepilone) (oncology)
JAK2 inhibitor (oncology) Dapagliflozin (metabolics) ONGLYZA™ (saxagliptin) (metabolics)
IGF-1R antagonist (oncology) Belatacept (immunoscience) ORENCIA® (abatacept) (immunoscience)
SMO antagonist (oncology) Apixaban (cardiovascular) PLAVIX® (clopidogrel bisulfate tablets) (cardiovascular)
Cdc7 inhibitor (oncology) AVAPRO® (irbesartan) AVALIDE® (irbesartan-
hydrochlorothiazide) (cardiovascular)

RAF Kinase inhibitor (oncology)

BARACLUDE® (entecavir) (virology)
Elotuzumab (Anti-CS1) (oncology) REYATAZ® (atazanavir sulfate) (virology)
Anti-CD137 (oncology) SUSTIVA® (efavirenz) ATRIPLA® (efavirenz / emtricitabine / tenofovir disoproxil fumarate) (virology)
Anti-CD19 (oncology) ABILIFY® (aripiprazole) (neuroscience)
Anti-PDL1 (oncology)

Anti-PD1 (oncology)

Anti-CD70 ADC (oncology)
Anti-CXCR4 (oncology)
Notch inhibitor (oncology)
MCHR1 antagonist (metabolics)
Glucokinase activator (metabolics)
11βHSD inhibitors (metabolics)
DGAT inhibitor (metabolics)
CCR2 antagonist (metabolics)
GPR119 agonist (metabolics)
CCR1 antagonists (immunoscience)
p38 Kinase inhibitor (immunoscience)
Anti-CD28 (immunoscience)
Anti-IL6 (immunoscience)
IL-23 Adnectin (immunoscience)
Anti-IFNα (immunoscience)
Anti-IP10 (immunoscience)
LXR modulators (cardiovascular)
PCSK9 inhibitor (cardiovascular)
CCR2 / 5 antagonist(cardiovascular)
IKACh inhibitor (cardiovascular)
Delta PKC inhibitor (cardiovascular)
NS3 inhibitor (virology)
NS5B inhibitor (virology)
NS5A inhibitors (virology)
PEG Interferon λ
(virology)
HIV Attachment inhibitor (virology)
Triple Reuptake inhibitors (neuroscience)
Microtubule stabilizer (neuroscience)
Gamma Secretase inhibitor (neuroscience)
AGN-209323 (neuroscience)
CGRP antagonist (neuroscience)

Please click on product name to see the Full Prescribing Information for ABILIFY®, ATRIPLA®, AVAPRO®/AVALIDE®, BARACLUDE®, ERBITUX®, IXEMPRA®, ONGLYZA™, ORENCIA®, PLAVIX®, REYATAZ®, SPRYCEL®, SUSTIVA®, including boxed WARNINGS for ABILIFY®, ATRIPLA®, BARACLUDE®, ERBITUX®, IXEMPRA™, and TAXOL®, and boxed WARNINGS for AVAPRO® and AVALIDE® regarding use in pregnancy. As soon as pregnancy is detected, discontinue use of AVAPRO® or AVALIDE®.

Exploratory Development compounds are investigational drugs that are post discovery through Phase II.

Full Development compounds are investigational drugs that are in late-stage clinical development, or have been submitted to regulatory agencies for approval.

Marketed Product Development compounds have been approved in at least one major market and are among approved medicines that are driving current and future growth while continuing their clinical development to determine whether additional indications and formulations will benefit patients.

Like any other scientific endeavor, clinical testing of novel drug compounds is a complex, time-consuming, resource-intensive process with no guaranteed results. But, as described here, Bristol-Myers Squibb is committed to pursuing such clinical development and, in doing so, to bringing new hope to patients.